A phase III study of radiation therapy plus carmustine with or without recombinant interferon-alpha in the treatment of patients with newly diagnosed high-grade glioma.

@article{Buckner2001API,
  title={A phase III study of radiation therapy plus carmustine with or without recombinant interferon-alpha in the treatment of patients with newly diagnosed high-grade glioma.},
  author={Jan C. Buckner and Paula J. Schomberg and William L McGinnis and Terrence L. Cascino and Bernd Walter Scheithauer and J R O'fallon and Roscoe F. Morton and Steven A. Kuross and James A. Mailliard and Alan K. Hatfield and John T. Cole and Preston D. Steen and Albert M. Bernath},
  journal={Cancer},
  year={2001},
  volume={92 2},
  pages={420-33}
}
BACKGROUND The current study was conducted to determine whether the addition of interferon-alpha (IFN-alpha) to treatment with radiation therapy and carmustine (BCNU) improves time to disease progression or overall survival in patients with high-grade glioma. METHODS Patients with anaplastic astrocytoma, anaplastic oligoastrocytoma, glioblastoma multiforme, or gliosarcoma received radiation therapy plus BCNU as initial therapy. Subsequently, patients without tumor progression at the… CONTINUE READING

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