A phase II study of preoperative capecitabine and radiation therapy in patients with rectal cancer.

@article{Desai2007API,
  title={A phase II study of preoperative capecitabine and radiation therapy in patients with rectal cancer.},
  author={Sameer P Desai and Basil F. El-Rayes and Edgar Ben-Josef and Joel K. Greenson and James A. Knol and Emina Huang and Kent A. Griffith and Philip Agop Philip and Cornelius J. Mcginn and Mark M. Zalupski},
  journal={American journal of clinical oncology},
  year={2007},
  volume={30 4},
  pages={340-5}
}
OBJECTIVES The purpose of this study was to evaluate the safety and efficacy of preoperative capecitabine and radiation therapy (RT) in patients with locally advanced rectal cancer (LARC). METHODS Patients with adenocarcinoma of the rectum stage >or=T3 or >or=N1 were treated with capecitabine 1330 mg/m per day in 2 divided doses days 1 to 42 and 50.4 Gy of RT in 28 1.8-Gy fractions. Patients with metastatic disease were eligible provided that operative intervention on primary site was… CONTINUE READING
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