A phase II study of irinotecan with bi-weekly, low-dose leucovorin and bolus and continuous infusion 5-fluorouracil (modified FOLFIRI) as salvage therapy for patients with advanced or metastatic gastric cancer.

@article{Kim2007API,
  title={A phase II study of irinotecan with bi-weekly, low-dose leucovorin and bolus and continuous infusion 5-fluorouracil (modified FOLFIRI) as salvage therapy for patients with advanced or metastatic gastric cancer.},
  author={Seong-Geun Kim and Sung Yong Oh and Hyuk-Chan Kwon and Suee Lee and Jung Hwan Kim and Sung-Hyun Kim and Hyo-Jin Kim},
  journal={Japanese journal of clinical oncology},
  year={2007},
  volume={37 10},
  pages={744-9}
}
OBJECTIVE This phase II study was designed to assess the safety and efficacy of a modified FOLFIRI regimen (irinotecan with bi-weekly, low dose leucovorin (ldLV) and bolus and continuous infusion with 5-fluorouracil (5-FU)) as a salvage therapy for patients with advanced or metastatic gastric cancer. METHODS Patients were treated with irinotecan 150 mg/m(2) on day 1 and received ldLV 20 mg/m(2) followed by 5-FU 400 mg/m(2) (bolus) and 5-FU 600 mg/m(2) (22 h continuous infusion) on days 1 and… CONTINUE READING