A phase II study of ifosfamide in advanced and relapsed carcinoma of the cervix

  title={A phase II study of ifosfamide in advanced and relapsed carcinoma of the cervix},
  author={Robert Coleman and Peter G. Harper and Chris J Gallagher and R. Travis Osborne and Elaine M. Rankin and Anthony C Silverstone and Maurice L. Slevin and Robert L. Souhami and Jeffrey S. Tobias and Colin W Trask and Eve Wiltshaw},
  journal={Cancer Chemotherapy and Pharmacology},
Forty-one patients with advanced progressing carcinoma of the cervix were treated with ifosfamide 1.5 g/m2 daily in a 30-min infusion for 5 days every 3 weeks. The overall response rate (complete + partial) was 12/39 (31%), or 12/30 (40%) in those who had not received previous chemotherapy. Six patients achieved a complete remission of disease and four of these remain disease-free 24–39 months later. Durable response were seen in patients with disease progressing after radical radiotherapy… CONTINUE READING
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