A phase II evaluation of tamoxifen in unresectable or refractory meningiomas: a southwest oncology group study

@article{Goodwin1993API,
  title={A phase II evaluation of tamoxifen in unresectable or refractory meningiomas: a southwest oncology group study},
  author={John Wendall Goodwin and John C Crowley and Harmon J. Eyre and Benjamin Stafford and Kurt A. Jaeckle and Jeannette J. Townsend},
  journal={Journal of Neuro-Oncology},
  year={1993},
  volume={15},
  pages={75-77}
}
Twenty-one patients with nonresectable refractory meningiomas were registered on a study giving tamoxifen 40 mg per M2 b.i.d. for four days, then 10 mg b.i.d. thereafter. Nineteen were eligible and evaluated for response. One patient (5%) achieved an MRI-documented partial response while two had a minor response measured on CT scan which was of short duration (4 and 20 months). Six patients (32%) remained stable for a median duration of 31 + months while ten (53%) demonstrated progression… CONTINUE READING

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