A phase I trial of pharmacokinetic modulation of carboxyamidotriazole (CAI) with ketoconazole in patients with advanced cancer

@article{Desai2004API,
  title={A phase I trial of pharmacokinetic modulation of carboxyamidotriazole (CAI) with ketoconazole in patients with advanced cancer},
  author={Apurva A. Desai and Federico Innocenti and Linda Janisch and Mark Demario and Dale Shepard and Jacqueline Ram{\'i}rez and Gini F. Fleming and Mark J. Ratain},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2004},
  volume={54},
  pages={377-384}
}
Carboxyamidotriazole (CAI) is a novel antineoplastic agent in clinical development with limited oral bioavailability. In vitro, ketoconazole has been demonstrated to inhibit CYP3A4-mediated metabolism of CAI. We performed this phase I trial to determine if ketoconazole-mediated CYP3A4 inhibition would lead to favorable alteration of CAI pharmacokinetics, and to evaluate the safety, toxicity and tolerability of the proposed combination. Forty-seven patients were treated using a standard three… CONTINUE READING

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