A phase I study of radiation therapy (RT) with concurrent oxaliplatin (OXL), cisplatin (P) and protacted infusion 5-fluorouracil (FU) for locally advanced esophageal (ES) or gastroesophageal (GEJ) carcinoma.


4243 Background: Concurrent chemoradiotherapy with P and FU is superior to RT alone for locally advanced ES and GEJ carcinoma (Herskovic NEJM 1992) but at the cost of substantial toxicity. OXL has demonstrated activity in gastrointestinal tumors and overcome mismatch repair cisplatin-resistance in vitro. This study was undertaken to assess toxicity in… (More)