A phase I study of neoadjuvant chemotherapy with nanoparticle albumin-bound paclitaxel, doxorubicin, and cyclophosphamide (NAC) in patients with stages II-III HER2-negative breast cancer.

Abstract

e11519^ Background: The TAC regimen (docetaxel, doxorubicin, and cyclophosphamide) is among the most active drug combinations in the adjuvant and neoadjuvant settings. A recent study demonstrated that weekly nab-paclitaxel (N) is superior to every-three week docetaxel in both efficacy and toxicity in patients with metastatic breast cancer. Here we report… (More)

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