A phase-I study of an anti-CD25 ricin A-chain immunotoxin (RFT5-SMPT-dgA) in patients with refractory Hodgkin's lymphoma.

  title={A phase-I study of an anti-CD25 ricin A-chain immunotoxin (RFT5-SMPT-dgA) in patients with refractory Hodgkin's lymphoma.},
  author={Andreas Engert and Volker Diehl and R. Schnell and A Radszuhn and M T Hatwig and S. Drillich and Gisela Sch{\"o}n and Heribert Bohlen and Hans Tesch and Martin-Leo Hansmann and Stefan Barth and John D Schindler and Victor F Ghetie and Jonathan W. Uhr and Ellen S. Vitetta},
  volume={89 2},
The anti-CD25 immunotoxin (IT), RFT5-SMPT-dgA, was used in a phase I dose escalation trial in patients with refractory Hodgkin's lymphoma. The IT was constructed by linking the monoclonal antibody RFT5 via a sterically hindered disulfide linker to deglycosylated ricin-A. All patients in this trial were heavily pretreated with a mean of 5 (range, 2 to 8) different prior therapies, including autologous bone marrow transplantation in 8 of 15. The mean age was 29 years (range, 19 to 34 years… CONTINUE READING


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