A phase-I study of an anti-CD25 ricin A-chain immunotoxin (RFT5-SMPT-dgA) in patients with refractory Hodgkin's lymphoma.

@article{Engert1997APS,
  title={A phase-I study of an anti-CD25 ricin A-chain immunotoxin (RFT5-SMPT-dgA) in patients with refractory Hodgkin's lymphoma.},
  author={Andreas Engert and Volker Diehl and Roland Schnell and Andrea Radszuhn and M. T. Hatwig and S. Drillich and Gisela Sch{\"o}n and Heribert Bohlen and Hans Tesch and Martin Leo Hansmann and Sandra Barth and John Schindler and Victor F Ghetie and Jonathan W. Uhr and Ellen S. Vitetta},
  journal={Blood},
  year={1997},
  volume={89 2},
  pages={
          403-10
        }
}
  • Andreas Engert, Volker Diehl, +12 authors Ellen S. Vitetta
  • Published 1997
  • Medicine
  • Blood
  • The anti-CD25 immunotoxin (IT), RFT5-SMPT-dgA, was used in a phase I dose escalation trial in patients with refractory Hodgkin's lymphoma. The IT was constructed by linking the monoclonal antibody RFT5 via a sterically hindered disulfide linker to deglycosylated ricin-A. All patients in this trial were heavily pretreated with a mean of 5 (range, 2 to 8) different prior therapies, including autologous bone marrow transplantation in 8 of 15. The mean age was 29 years (range, 19 to 34 years… CONTINUE READING

    Paper Mentions

    INTERVENTIONAL CLINICAL TRIAL
    This clinical trial will be a multicenter phase II fixed-dose trial in which a minimum of 10 patients with immunophenotypically confirmed ATL with at least 50% of the blasts expressing… Expand
    ConditionsAdult T Cell Leukemia, Adult T Cell Lymphoma
    InterventionDrug, Other

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