A phase I pilot study of pelvic radiation and alpha-2A interferon in patients with locally advanced or recurrent rectal cancer.

@article{Perera1997API,
  title={A phase I pilot study of pelvic radiation and alpha-2A interferon in patients with locally advanced or recurrent rectal cancer.},
  author={Francisco E. Perera and Barbara Jean Fisher and Walter Ilarion Kocha and E A Plewes and Marie Taylor and Mark David Vincent},
  journal={International journal of radiation oncology, biology, physics},
  year={1997},
  volume={37 2},
  pages={297-303}
}
PURPOSE The purpose of this pilot study was to determine the maximum tolerated dose of alpha-2a interferon given by subcutaneous injection and combined with high dose pelvic radiation for locally advanced or recurrent rectal cancer. METHODS AND MATERIALS In this Phase I pilot study, patients with locally advanced, unresectable, or recurrent rectal cancer with or without distant metastases received external beam pelvic radiotherapy over 5 to 6 weeks combined with escalating doses of alpha-2a… CONTINUE READING