A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors

@article{Raez2012API,
  title={A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors},
  author={L. Raez and K. Papadopoulos and A. Ricart and E. Chiorean and R. DiPaola and Mark N. Stein and C. R. Rocha Lima and J. Schlesselman and K. Tolba and V. Langmuir and S. Kroll and D. Jung and M. Kurtoğlu and J. Rosenblatt and T. Lampidis},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2012},
  volume={71},
  pages={523-530}
}
PurposeThis phase I trial was initiated to evaluate the safety, pharmacokinetics (PK) and maximum tolerated dose (MTD) of the glycolytic inhibitor, 2-deoxy-d-glucose (2DG) in combination with docetaxel, in patients with advanced solid tumors.MethodsA modified accelerated titration design was used. 2DG was administered orally once daily for 7 days every other week starting at a dose of 2 mg/kg and docetaxel was administered intravenously at 30 mg/m2 for 3 of every 4 weeks beginning on day 1 of… Expand
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Paper Mentions

Interventional Clinical Trial
The objectives of this study are to evaluate the safety, tolerability, pharmacokinetics, and biologic effect (FDG PET, preliminary efficacy) of daily oral doses of 2DG with and without… Expand
ConditionsBreast Cancer, Gastric Cancer, Head and Neck Cancer, (+2 more)
InterventionDrug
Rescue of 2-Deoxyglucose Side Effects by Ketogenic Diet
2-Deoxy-d-Glucose Ameliorates PKD Progression.
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