A phase I clinical trial of recombinant human tumor necrosis factor given daily for five days

@article{Creaven1989API,
  title={A phase I clinical trial of recombinant human tumor necrosis factor given daily for five days},
  author={Patrick J. Creaven and Dean E. Brenner and J. Wayne Cowens and Robert P. Huben and Richard M. Wolf and Hiroshi Takita and Susan G. Arbuck and Mohamed S. Razack and April D. Proefrock},
  journal={Cancer Chemotherapy and Pharmacology},
  year={1989},
  volume={23},
  pages={186-191}
}
A phase I trial of human recombinant tumor necrosis factor (rH-TNF) has been carried out in patients with advanced solid tumors. Sixty-six courses of the drug were given by 1 h IV infusion, daily for 5 days to 33 patients at doses of 5, 10, 20, 30, 45, 60, and 80x104 U/m2/day. All patients received isotonic saline (up to 21/day) and either indomethacin or ketoprofen. Acute toxicity resembled that seen with the phase I study of a single dose (5). Dose limiting toxicity was acute, rapidly… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 22 references

Tumor necrosis factor: phase I trial of a daily x 5 schedule

  • PJ Creaven, DE Brenner, +6 authors JK Solomon
  • Proc Am Soc Clin Oncol
  • 1988
2 Excerpts

Clinical studies of recombinant human tumor necrosis factor ( rHuTNF )

  • T Taguchi
  • Immunobiology
  • 1987

Early clinical studies of recombinant human tumor necrosis factor

  • P Selby, S Hobbs, E Jackson, C Viner
  • 1987

Phase I studies of rTNF-ct in a patients with advanced cancer

  • JL Gabrilove, HF Starnes, +8 authors HF Oettgen
  • Immunobiology
  • 1987
2 Excerpts

Phase I study of intratumoral ( i . t . ) and intravenous ( i . v . ) application of recombinant human tumor necrosis factor ( rHuTNF ) in patients with malignant diseases

  • SteinmetzT, M Schaadt, R Tuschen, M Pfreundschuh, V Diehl
  • Immunobiology
  • 1987

Phase I study of recombinant human tumor necrosis factor

  • K Kimura, T Taguchi, +4 authors T Hattori
  • Cancer Chemother Pharmacol
  • 1987

Phase I study of recombinant human tumor necrosis factor in patients with advanced malignancies

  • T Moritz, N Niederle, E Kurschel, D May, E Schlick, CG Schmidt
  • Immunobiology
  • 1987

Similar Papers

Loading similar papers…