A phase I biological and pharmacologic study of the heparanase inhibitor PI-88 in patients with advanced solid tumors.

@article{Basche2006API,
  title={A phase I biological and pharmacologic study of the heparanase inhibitor PI-88 in patients with advanced solid tumors.},
  author={Michele L. Basche and Daniel L. Gustafson and Scott N. Holden and Cindy L O'bryant and Lia Gore and Samir E. Witta and Mary Kay Schultz and Mark Morrow and Adrah Levin and Brian R. Creese and Michael Kangas and Kaye L. Roberts and Thu H.M. Nguyen and Kat Davis and Russell S Addison and Jane C Moore and S. Gail Eckhardt},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2006},
  volume={12 18},
  pages={5471-80}
}
PURPOSE PI-88 is a mixture of highly sulfated oligosaccharides that inhibits heparanase, an extracellular matrix endoglycosidase, and the binding of angiogenic growth factors to heparan sulfate. This agent showed potent inhibition of placental blood vessel angiogenesis as well as growth inhibition in multiple xenograft models, thus forming the basis for this study. EXPERIMENTAL DESIGN This study evaluated the toxicity and pharmacokinetics of PI-88 (80-315 mg) when administered s.c. daily for… CONTINUE READING
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