A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin

@article{Schoemaker2002API,
  title={A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin},
  author={Nadja E. Schoemaker and Charlotte van Kesteren and Hilde Rosing and Sepp R. Jansen and Martha Swart and Jan Lieverst and Daniela Fraier and Massimo Breda and Cinzia Pellizzoni and Riccardo Spinelli and Maria Grazia Porro and Jos H. Beijnen and Jan H. M. Schellens and W. W. ten Bokkel Huinink},
  journal={British Journal of Cancer},
  year={2002},
  volume={87},
  pages={608 - 614}
}
Polymeric drug conjugates are a new and experimental class of drug delivery systems with pharmacokinetic promises. The antineoplastic drug camptothecin was linked to a water-soluble polymeric backbone (MAG-CPT) and administrated as a 30 min infusion over 3 consecutive days every 4 weeks to patients with malignant solid tumours. The objectives of our study were to determine the maximal tolerated dose, the dose-limiting toxicities, and the plasma and urine pharmacokinetics of MAG-CPT, and to… CONTINUE READING

11 Figures & Tables

Connections & Topics

Mentioned Connections BETA
The antineoplastic drug camptothecin was linked to a water - soluble polymeric backbone ( MAG - CPT ) and administrated as a 30 min infusion over 3 consecutive days every 4 weeks to patients with malignant solid tumours .
The antineoplastic drug camptothecin was linked to a water - soluble polymeric backbone ( MAG - CPT ) and administrated as a 30 min infusion over 3 consecutive days every 4 weeks to patients with malignant solid tumours .
The antineoplastic drug camptothecin was linked to a water - soluble polymeric backbone ( MAG - CPT ) and administrated as a 30 min infusion over 3 consecutive days every 4 weeks to patients with malignant solid tumours .
MAG - CPT and free camptothecin were accumulated during days 1–3 and considerable amounts of MAG - CPT could still be retrieved in plasma and urine after 4–5 weeks .
MAG - CPT and free camptothecin were accumulated during days 1–3 and considerable amounts of MAG - CPT could still be retrieved in plasma and urine after 4–5 weeks .
The antineoplastic drug camptothecin was linked to a water - soluble polymeric backbone ( MAG - CPT ) and administrated as a 30 min infusion over 3 consecutive days every 4 weeks to patients with malignant solid tumours .
The antineoplastic drug camptothecin was linked to a water - soluble polymeric backbone ( MAG - CPT ) and administrated as a 30 min infusion over 3 consecutive days every 4 weeks to patients with malignant solid tumours .
The antineoplastic drug camptothecin was linked to a water - soluble polymeric backbone ( MAG - CPT ) and administrated as a 30 min infusion over 3 consecutive days every 4 weeks to patients with malignant solid tumours .
The antineoplastic drug camptothecin was linked to a water - soluble polymeric backbone ( MAG - CPT ) and administrated as a 30 min infusion over 3 consecutive days every 4 weeks to patients with malignant solid tumours .
MAG - CPT and free camptothecin were accumulated during days 1–3 and considerable amounts of MAG - CPT could still be retrieved in plasma and urine after 4–5 weeks .
MAG - CPT and free camptothecin were accumulated during days 1–3 and considerable amounts of MAG - CPT could still be retrieved in plasma and urine after 4–5 weeks .
All Topics