A phase I/II study of the intralesional injection of ricin-monoclonal antibody conjugates in patients with hepatic metastases.

@article{Zalcberg1994API,
  title={A phase I/II study of the intralesional injection of ricin-monoclonal antibody conjugates in patients with hepatic metastases.},
  author={John R Zalcberg and Geoffrey A. Pietersz and Brendan Toohey and John R. Laird and Richard Huggins and Alan Zimet and Oliver F. Hennessy and A Mckenzie and Ian F.C. Mckenzie},
  journal={European journal of cancer},
  year={1994},
  volume={30A 9},
  pages={1227-31}
}
A phase I/II study of the intralesional administration of ricin-labelled monoclonal antibodies was conducted in patients with hepatic metastases of gastrointestinal origin. The anti-carcinoembryonic antigen (CEA) antibody I-1 was conjugated to blocked ricin via a disulphide bridge. After a test dose of antibody, patients were injected with ricin-antibody conjugates under computed tomography (CT) guidance on two occasions 1 week apart. Patients with stable or responding disease would receive a… CONTINUE READING