A phase I/II study of intraoperative radiotherapy in advanced unresectable or recurrent carcinoma of the rectum: a Radiation Therapy Oncology Group (RTOG) study.

@article{Lanciano1993API,
  title={A phase I/II study of intraoperative radiotherapy in advanced unresectable or recurrent carcinoma of the rectum: a Radiation Therapy Oncology Group (RTOG) study.},
  author={Rachelle Lanciano and Allison Calkins and Harvey B Wolkov and Jan W. Buzydlowski and Robert Dirk Noyes and Willliam T Sause and Diane F. Nelson and Christopher G Willett and J Cuthbert Owens and G M Hanks},
  journal={Journal of surgical oncology},
  year={1993},
  volume={53 1},
  pages={20-9}
}
The Radiation Therapy Oncology Group (RTOG) initiated a phase I/II study of intraoperative radiotherapy (IORT) in advanced or recurrent rectal cancer to assess therapeutic efficacy, toxicity, and establish quality control guidelines prior to beginning a phase III trial. From October 1985 through December 1989, 87 patients with histologically proven adenocarcinoma of the rectum or rectosigmoid with recurrent/persistent disease after surgery or those primarily inoperable were entered by 14… CONTINUE READING