A phase I/II study of combined weekly systemic cisplatin and locoregional hyperthermia in patients with previously irradiated recurrent carcinoma of the uterine cervix

@article{Wit1999API,
  title={A phase I/II study of combined weekly systemic cisplatin and locoregional hyperthermia in patients with previously irradiated recurrent carcinoma of the uterine cervix},
  author={Ronald de Wit and Jacoba van der Zee and M. E. L. van der Burg and Wim H. J. Kruit and Adriaan Logmans and Gerard C. van Rhoon and Jaap Verweij},
  journal={British Journal of Cancer},
  year={1999},
  volume={80},
  pages={1387 - 1391}
}
SummaryWe investigated the feasibility and the anti-tumour activity of weekly cisplatin and the simultaneous application of local hyperthermia in patients with a pelvic recurrence of cervical cancer in previously irradiated area. Dose levels of cisplatin 60 mg m–2, 70 mg m–2 and 80 mg m–2 were studied. Treatment objective of hyperthermia was the achievement of a tumour temperature of ≥ 42° for 60 min, during cisplatin administration. The protocol advised six weekly cycles of combined treatment… CONTINUE READING

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