A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression

@article{Nagele2021AP2,
  title={A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression},
  author={Peter Nagele and Ben Julian A Palanca and Britt M. Gott and Frank Brown and Linda Barnes and Thomas Nguyen and Willa Xiong and Naji C Salloum and Gemma D. Espejo and Christina N. Lessov-Schlaggar and Nisha Jain and Wayland W. L. Cheng and Helga Komen and Branden Yee and Jacob D. Bolzenius and Alvin Janski and Robert Gibbons and Charles F. Zorumski and Charles R. Conway},
  journal={Science Translational Medicine},
  year={2021},
  volume={13}
}
Twenty-five percent inhaled nitrous oxide improves symptoms of treatment-resistant major depression with fewer adverse effects than the 50% concentration. Laughing gas improves depression About one-third of individuals suffering from depression are at risk for treatment resistance. Whereas inhaled 50% nitrous oxide has early antidepressant effects on individuals with treatment-resistant major depression (TRMD), adverse effects can occur at this concentration. In this phase 2 clinical trial… 
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