A phase 2, single-arm study of an autologous dendritic cell treatment against mucin 1 in patients with advanced epithelial ovarian cancer

@inproceedings{Mitchell2014AP2,
  title={A phase 2, single-arm study of an autologous dendritic cell treatment against mucin 1 in patients with advanced epithelial ovarian cancer},
  author={Paul L. R. Mitchell and Michael A. Quinn and Peter T Grant and David G Allen and Thomas W. Jobling and Shane C. White and Anne Y Zhao and Vaios Karanikas and Hilary Vaughan and Geoffrey A. Pietersz and I F C Mckenzie and Sharron E. Gargosky and Bruce Edward Loveland},
  booktitle={Journal for immunotherapy of cancer},
  year={2014}
}
BACKGROUND Mucin 1 antigen, highly expressed by epithelial ovarian cancer (EOC), is a potential target for immunotherapy. A previous successful phase 1 trial was conducted in patients with adenocarcinoma who were injected with Cvac, autologous monocyte-derived dendritic cells (DCs) incubated with mannosylated mucin 1 protein (M-FP). The present study was a phase 2 trial of Cvac in patients with advanced EOC. METHODS Eligible patients had EOC with progressive disease, defined as an increase in… CONTINUE READING
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