A phase 1b study of placenta-derived mesenchymal stromal cells in patients with idiopathic pulmonary fibrosis.

@article{Chambers2014AP1,
  title={A phase 1b study of placenta-derived mesenchymal stromal cells in patients with idiopathic pulmonary fibrosis.},
  author={Daniel C Chambers and Debra Enever and Nina Ili{\'c} and Lisa M Sparks and Kylie Whitelaw and John Ayres and Stephanie T Yerkovich and Dalia Khalil and Kerry M Atkinson and Peter M. A. Hopkins},
  journal={Respirology},
  year={2014},
  volume={19 7},
  pages={1013-8}
}
BACKGROUND AND OBJECTIVE Idiopathic pulmonary fibrosis (IPF) is a degenerative disease characterized by fibrosis following failed epithelial repair. Mesenchymal stromal cells (MSC), a key component of the stem cell niche in bone marrow and possibly other organs including lung, have been shown to enhance epithelial repair and are effective in preclinical models of inflammation-induced pulmonary fibrosis, but may be profibrotic in some circumstances. METHODS In this single centre, non… CONTINUE READING
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