A pharmacoproteomic study confirms the synergistic effect of chondroitin sulfate and glucosamine

@article{Calamia2014APS,
  title={A pharmacoproteomic study confirms the synergistic effect of chondroitin sulfate and glucosamine},
  author={Valentina Calamia and Jes{\'u}s Mateos and Patricia Fern{\'a}ndez‐Puente and Luc{\'i}a Lourido and Beatriz Rocha and Carolina Fern{\'a}ndez-Costa and Eulàlia Montell and Josep Verg{\'e}s and Cristina Ruiz-Romero and Francisco J. Blanco},
  journal={Scientific Reports},
  year={2014},
  volume={4}
}
Osteoarthritis (OA) is the most common age-related rheumatic disease. Chondrocytes play a primary role in mediating cartilage destruction and extracellular matrix (ECM) breakdown, which are main features of the OA joint. Quantitative proteomics technologies are demonstrating a very interesting power for studying the molecular effects of some drugs currently used to treat OA patients, such as chondroitin sulfate (CS) and glucosamine (GlcN). In this work, we employed the iTRAQ (isobaric tags for… Expand
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TLDR
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TLDR
A review of randomized, controlled trials published from that time to the present finds the findings are mixed, owing in some cases to the high rate of placebo response added to by the ethical incorporation of rescue analgesics into protocols designed to evaluate the slow-acting, subtle effects of glucosamine and chondroitin sulfate in combination. Expand
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TLDR
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TLDR
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Impact of Prevalence Ratios of Chondroitin Sulfate (CS)- 4 and -6 Isomers Derived from Marine Sources in Cell Proliferation and Chondrogenic Differentiation Processes
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