A pharmacological comparison of 3-methoxy-4,5-methylenedioxyamphetamine and LSD in the dog.

  title={A pharmacological comparison of 3-methoxy-4,5-methylenedioxyamphetamine and LSD in the dog.},
  author={M. Nozaki and D. Bruce Vaupel and L D Bright and William R. Martin},
  journal={Drug and alcohol dependence},
  volume={3 3},
3-Methoxy-4,5-methylenedioxyamphetamine (MMDA), which has been reported to have hallucinogenic actions in man, was compared to LSD in single dose, antagonist interaction, cross-tolerance and appetite suppression studie in the dog. In single doses, MMDA partially resembled LSD: both facilitated the flexor reflex and produced tachypnea, hyperthermia, and analgesia; however, MMDA had greater activity than LSD in producing mydriasis. Only LSD consistently elicited the stepping reflex and produced… 
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Methamphetamine‐induced Neurotoxicity: Structure Activity Relationships
Structural similarities among amphetamine analogs which have been demonstrated to have effects consistent with neurotoxic activity are discussed, as well as some common neuropharmacological actions which may be related to druginduced neurotoxic effects.
Changes in body temperature after administration of antipyretics, LSD, Δ9-THC and related agents: II
  • W. G. Clark
  • Medicine
    Neuroscience & Biobehavioral Reviews
  • 1987
This compilation primarily covers the considerable amount of data published from 1981 through 1985 on the interactions of these drugs and thermoregulation, but data from many earlier papers not included in a previous compilation are also tabulated.
Changes in body temperature after administration of adrenergic and serotonergic agents and related drugs including antidepressants
This survey, the third in a series, presents extensive tabulations of literature, primarily since 1965, on thermoregulatory effects of adrenergic and serotonergic agonists and their antagonists
Intrasynaptosomal Sequestration of [3H]Amphetamine and [3H]Methylenedioxyamphetamine: Characterization Suggests the Presence of a Factor Responsible for Maintaining Sequestration
Saturation studies, using increasing concentrations of nonradioactive ligand, revealed that [3H]‐MDA interacted with two saturable sites that were sensitive to boiling of the tissue, indicating that [ 3H]MDA incorporation into synaptosomes may represent an internalization and sequestration phenomenon.
Cigarette Smoking, Substance Abuse, Nutritional Status, and Immune Function
No clear hypotheses of causal biological links between tobacco smoke components, specific drugs, specific nutritional deficiencies, and specific syndromes of immune dysfunction have been proposed and tested.


A pharmacologic comparison of 2,5-dimethoxyamphetamine and LSD in the chronic spinal dog
Abstract Intravenous infusions of 2,5-dimethoxyamphetamine (2.4 mg/kg) and LSD (10 μg/kg) in the chronic spinal dog facilitated the flexor reflex, elicited the stepping reflex, increased respiration,
Evidence for a difference in mechanism of action between fenfluramine‐ and amphetamine‐induced anorexia
The present results together with other evidence discussed support the conclusion that 5‐HT mechanisms are involved in fenfluramine anorexia, whereas amphetamineAnorexia seems mainly correlated with catecholamine dependent mechanisms.
The identification of LSD-like hallucinogens using the chronic spinal dog.
The results of these studies indicate that psilocin, mescaline, dimethyltryptamine and tryptamine are LSD-like drugs, and DOM, DOB, DMA, and TMA are predominantly LSD- like drugs but do have some amphetamine-like action.
Anorexigenic effects of d-amphetamine and 1-dopa in the rat
The data show that the anorexigenic effect of amphetamine and l-dopa are similar and indicate a functional role for both norepinephrine and dopamine neurons in feeding behaviour in the rat.
Action of psychotogenic drugs on single midbrain raphe neurons.
The results indicate that the indole and phenethylamine psychotogens, which have similar effects on behavior, also have an overlapping although not identical effect on single units in the raphe nuclei.
Studies on lysergic acid diethylamide (LSD-25). III. Attempts to attenuate the LSD-reaction in man by pretreatment with neurohumoral blocking agents.
A hypothesis which ascribes the LSD psychosis to competition between LSD and serotonin for receptor sites on or in neurons, which might be termed the serotonin-deficiency theory, is based in part on the following evidence: Serotonin is found in brain, 6.
Interactions between norepinephrine antagonists and potentiators (chlorpromazine, chlorpromazine sulfoxide and imipramine) and sympathetic amines (amphetamine and methoxamine) on the flexor reflex of the chronic spinal dog.
It has been concluded that the central adrenergic-blocking property of chlorpromazine predominates, whereas, the adren allergic-blocking and Adrenergic-potentiating effects of chlor Promazine sulfoxide and imipramine counterbalance each other.
Evidence for a central 5‐hydroxytryptamine receptor stimulation by lysergic acid diethylamide
It was found that LSD reduced the turnover rate of brain and spinal cord 5‐HT, studied after inhibition of the tryptophan hydroxylase by α‐propyldopacet‐amide, which indicates that LSD stimulates central 5-HT receptors.
Dopamine and 5-hydroxytryptamine inhibit feeding in rats.
  • Z. Kruk
  • Medicine
    Nature: New biology
  • 1973
The experiments described here were designed to investigate the neurotransmitters involved in mediating anorectic responses in rats and suggest 5-hydroxytryptamine (5-HT) is involved in the anorectica action of fenfluramine.
Hindlimb reflexes of chronic spinal dots during cycles of addiction to morphine and methadon.
  • A. Wikler, K. Frank
  • Chemistry, Medicine
    The Journal of pharmacology and experimental therapeutics
  • 1948
Methods for preparing long-surviving, chronic spinal dogs, and methods for recording spontaneous activity and hindlimb reflexes in such preparations are described, and general signs of abstinence such as restlessness, tremors, fever, yawning, vomiting, lacrimation, rhinorrhea, and occasionally diarrhea appear at about the same time as the spontaneous activity in the hindlimbs.