A pharmacologic examination of receptors mediating serotonin-induced bronchoconstriction in the anesthetized guinea pig.

@article{Buckner1991APE,
  title={A pharmacologic examination of receptors mediating serotonin-induced bronchoconstriction in the anesthetized guinea pig.},
  author={Carl K. Buckner and Doris Dea and N J Liberati and Robert D. Krell},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1991},
  volume={257 1},
  pages={26-34}
}
The receptors involved in the bronchoconstriction evoked in vivo by intravenous administration to the anesthetized guinea pig of serotonin and serotonin-related agonists have been examined in this study. Animals were pretreated with indomethacin and (+/-)-propranolol to inhibit cyclooxygenase and beta adrenergic receptors, respectively, and pulmonary parameters were obtained with a Buxco pulmonary mechanics computer. Dose-dependent increases in pulmonary resistance and decreases in dynamic lung… CONTINUE READING

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