A pharmacologic comparison of histamine receptors in isolated extracranial and intracranial arteries in vitro.

@article{Edvinsson1975APC,
  title={A pharmacologic comparison of histamine receptors in isolated extracranial and intracranial arteries in vitro.},
  author={Lars Edvinsson and C H Owman},
  journal={Neurology},
  year={1975},
  volume={25 3},
  pages={271-6}
}
Isolated segments of cat extracranial and intracranial arteries were tested simultaneously for circular motor activity in an aerated Krebs-Ringer organ bath at constant temperature and pH. Histamine produced a strong contraction (about 850 dyn) in the extracranial arteries but a considerably weaker contraction, with a high half maximum response, in the… CONTINUE READING