A pharmacokinetic study of prednimustine as compared with prednisolone plus chlorambucil in cancer patients

@article{Bastholt2004APS,
  title={A pharmacokinetic study of prednimustine as compared with prednisolone plus chlorambucil in cancer patients},
  author={Lars Bastholt and Carl J. Johansson and Per Pfeiffer and Leif D Svensson and S A Johansson and Per Olov Gunnarsson and Henning T. Mouridsen},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2004},
  volume={28},
  pages={205-210}
}
SummaryThe pharmacokinetic characteristics of prednisolone and of chlorambucil and its β-oxidized metabolite, phenylacetic mustard (PAM) were studied in plasma after the oral administration of 200 mg prednimustine (Sterecyt) and a regimen consisting of 20 mg prednisolone plus 20 mg chlorambucil, respectively. A total of 12 cancer patients completed this trial. The drugs were given in a cross-over study as single doses, and serial plasma samples were collected for 32 h. Chlorambucil and PAM were… 
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Population pharmacokinetics identifies rapid gastrointestinal absorption and plasma clearance of oral chlorambucil administered to cats with indolent lymphoproliferative malignancies.

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Reactions of 4-bis(2-chloroethyl)aminophenylacetic acid (phenylacetic acid mustard) in physiological solutions

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Reactions of {4‐[Bis(2‐chloroethyl)amino]phenyl}acetic Acid (Phenylacetic Acid Mustard) with 2′‐Deoxyribonucleosides

Phenylacetic acid mustard (PAM) was found to be hydrolytically slightly more stable than CLB and the role of PAM–2′‐deoxyribonucleoside adducts on the cytotoxic and mutagenic properties of CLB is discussed.

References

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