A pharmacokinetic study of intermittent rifabutin dosing with a combination of ritonavir and saquinavir in patients infected with human immunodeficiency virus.

@article{Gallicano2001APS,
  title={A pharmacokinetic study of intermittent rifabutin dosing with a combination of ritonavir and saquinavir in patients infected with human immunodeficiency virus.},
  author={Keith D Gallicano and Yasmin Khaliq and G. R. Carignan and Andrew S Tseng and Sharon Walmsley and D William Cameron},
  journal={Clinical pharmacology and therapeutics},
  year={2001},
  volume={70 2},
  pages={149-58}
}
AIM Our primary aim was to evaluate the plasma exposures and safety of rifabutin and its active 25-O-desacetyl metabolite during concomitant therapy of intermittent rifabutin dosing regimens with a combination of ritonavir and saquinavir. METHODS Twenty-four patients without mycobacterial infection who were human immunodeficiency virus seropositive and who were receiving 400 mg each of ritonavir and saquinavir twice daily participated in a 3-period, 2-group longitudinal pharmacokinetic study… CONTINUE READING
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