A pharmacokinetic simulation model for ivabradine in healthy volunteers.

@article{Duffull2000APS,
  title={A pharmacokinetic simulation model for ivabradine in healthy volunteers.},
  author={Stephen B. Duffull and Sylvie Chabaud and Patrice Nony and Christian Laveille and Pascal Girard and Leon Aarons},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2000},
  volume={10 4},
  pages={285-94}
}
Ivabradine is a novel bradycardic agent that has been developed for the prevention of angina. Ivabradine has an active metabolite S-18982. The aim of this study is to develop a pharmacokinetic simulation model. Pharmacokinetic data from two studies were pooled and included data from a total of 66 healthy male volunteers. The data were collected following single dose intravenous and multiple dose oral administration of ivabradine. The multiple dose regimens were administered every 12 h and there… CONTINUE READING