A pharmacokinetic model of cis- and trans-permethrin disposition in rats and humans with aggregate exposure application.

@article{TorneroVelez2012APM,
  title={A pharmacokinetic model of cis- and trans-permethrin disposition in rats and humans with aggregate exposure application.},
  author={Rogelio Tornero-Velez and Jimena Davis and Edward J. Scollon and J M Starr and R. Woodrow Setzer and Michael-Rock Goldsmith and Daniel T. Chang and Jianping Xue and Valerie G. Zartarian and Michael J. Devito and Michael F Hughes},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2012},
  volume={130 1},
  pages={
          33-47
        }
}
Permethrin is a broad-spectrum pyrethroid insecticide and among the most widely used insecticides in homes and crops. Managing the risks for pesticides such as permethrin depends on the ability to consider diverse exposure scenarios and their relative risks. Physiologically based pharmacokinetic models of delta methrin disposition were modified to describe permethrin kinetics in the rat and human. Unlike formulated deltamethrin which consists of a single stereoisomer, permethrin is formulated… Expand
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The model captured well the toxicokinetics of permethrin isomers and their metabolites including the rapid absorption, the accumulation in fat, the extensive metabolism of the parent compounds, and the rapid elimination of metabolites in urine. Expand
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Toxicokinetics of cis- and trans-Permethrin: Influence of Isomer, Maturation and Sex.
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Elevated exposure of the immature brain appears to be instrumental in increased susceptibility to the acute neurotoxicity of high-dose permethrin, but it remains to be established whether age-dependent TK is relevant to long-term, low-level risks. Expand
Age Dependency of Blood-Brain Barrier Penetration by cis- and trans-Permethrin in the Rat
TLDR
D dissimilar BBB permeation does not contribute to the greater acute neurotoxic potency of CIS, but greater permeability of the immature BBB to CIS and TRANS may contributing to the increased susceptibility of preweanling rodents to the insecticides. Expand
Relationship between exposure, body burden and target tissue concentration after oral administration of a low-dose mixture of pyrethroid insecticides in young adult rats.
Pyrethroids (PYRs) are synthetic insecticides increasingly used in agricultural and household pest control. Little is known on how the toxicity of highly effective bolus doses of single compoundsExpand
Influence of Maturation on In Vivo Tissue to Plasma Partition Coefficients for Cis- and Trans-Permethrin.
TLDR
Data support the conclusion that age-dependent partitioning is an important determinant of the pharmacokinetics of permethrin and could influence the risk assessment of these insecticides in infants and children when incorporated into physiologically based pharmacokinetic models. Expand
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