A pharmacokinetic model of cis- and trans-permethrin disposition in rats and humans with aggregate exposure application.

  title={A pharmacokinetic model of cis- and trans-permethrin disposition in rats and humans with aggregate exposure application.},
  author={Rogelio Tornero-Velez and Jimena Davis and Edward J. Scollon and J M Starr and R. Woodrow Setzer and Michael-Rock Goldsmith and Daniel T. Chang and Jianping Xue and Valerie G. Zartarian and Michael J DeVito and Michael F. Hughes},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  volume={130 1},
Permethrin is a broad-spectrum pyrethroid insecticide and among the most widely used insecticides in homes and crops. Managing the risks for pesticides such as permethrin depends on the ability to consider diverse exposure scenarios and their relative risks. Physiologically based pharmacokinetic models of delta methrin disposition were modified to describe permethrin kinetics in the rat and human. Unlike formulated deltamethrin which consists of a single stereoisomer, permethrin is formulated… 

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