A pharmacokinetic and clinical review of the potential clinical impact of using different formulations of cyclosporin A. Berlin, Germany, November 19, 2001.

@article{Pollard2003APA,
  title={A pharmacokinetic and clinical review of the potential clinical impact of using different formulations of cyclosporin A. Berlin, Germany, November 19, 2001.},
  author={Stephen G. Pollard and Bjorn A P Nashan and Atholl Johnston and Peter F. Hoyer and Philip Belitsky and Paul Keown and Hal Helderman},
  journal={Clinical therapeutics},
  year={2003},
  volume={25 6},
  pages={1654-69}
}
A meeting of 14 transplant and pharmacokinetic specialists from Europe and North America was convened in November 2001 to evaluate scientific and clinical data regarding the use of different formulations of cyclosporin A (CsA). The following consensus was achieved. (1) CsA is a critical-dose drug with a narrow therapeutic window. Clinical outcomes after transplantation are affected by the pharmacokinetic properties of CsA, particularly by its bioavailability, and by intrapatient variability in… CONTINUE READING

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