A pharmacokinetic analysis program (multi) for microcomputer.


A nonlinear least squares program (MULTI) for microcomputers was developed. The program is written in BASIC programming language. Four algorithms, (1) Gauss-Newton method, (2) damping Gauss-Newton method, (3) modified Marquardt method and (4) simplex method, can be used for nonlinear curve fitting in MULTI. Up to five pharmacokinetic equations, which are… (More)


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@article{Yamaoka1981APA, title={A pharmacokinetic analysis program (multi) for microcomputer.}, author={K. Yamaoka and Yusuke Tanigawara and Takayuki Nakagawa and T Uno}, journal={Journal of pharmacobio-dynamics}, year={1981}, volume={4 11}, pages={879-85} }