A pharmacokinetic analysis program (multi) for microcomputer.

@article{Yamaoka1981APA,
  title={A pharmacokinetic analysis program (multi) for microcomputer.},
  author={Kiyoshi Yamaoka and Yusuke Tanigawara and Terumichi Nakagawa and Tadayuki Uno},
  journal={Journal of pharmacobio-dynamics},
  year={1981},
  volume={4 11},
  pages={879-85}
}
A nonlinear least squares program (MULTI) for microcomputers was developed. The program is written in BASIC programming language. Four algorithms, (1) Gauss-Newton method, (2) damping Gauss-Newton method, (3) modified Marquardt method and (4) simplex method, can be used for nonlinear curve fitting in MULTI. Up to five pharmacokinetic equations, which are voluntarily defined by the user, are simultaneously fitted to observed time courses. The executions of MULTI are demonstrated for time courses… CONTINUE READING
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