A pharmacokinetic/pharmacodynamic/receptor binding model to predict the onset and duration of pharmacological activity of the benzodiazepines

@article{Jack1983APB,
  title={A pharmacokinetic/pharmacodynamic/receptor binding model to predict the onset and duration of pharmacological activity of the benzodiazepines},
  author={M. Jack and W. Colburn and N. Spirt and G. Bautz and M. Žanko and W. D. Horst and R. O'brien},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={1983},
  volume={7},
  pages={629-635}
}
  • M. Jack, W. Colburn, +4 authors R. O'brien
  • Published 1983
  • Medicine, Chemistry
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
Ex vivo receptor binding as a function of time was determined in Charles River rats. The pharmacokinetic and protein binding parameters in man as well as the ex vivo receptor binding parameters in rat brain for three benzodiazepine induction agents, diazepam, lorazepam and midazolam, were used to develop and test a pharmacokinetic/pharmacodynamic/receptor binding model. The model was subsequently used to predict changes in receptor binding and pharmacodynamics as a function of changes in… Expand
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