A pharmacodynamic model for the action of the antibiotic imipenem on Pseudomonas aeruginosa populations in vitro.

@article{Berg1996APM,
  title={A pharmacodynamic model for the action of the antibiotic imipenem on Pseudomonas aeruginosa populations in vitro.},
  author={P. H. van den Berg and Eberhard O. Voit and Roger White},
  journal={Bulletin of mathematical biology},
  year={1996},
  volume={58 5},
  pages={923-38}
}
The standard method for measuring in vitro antibiotic efficacy is based on a point observation of bacterial activity 18 hours after inoculation. The method, while simple, forgoes significant information by ignoring the dynamics of the interactions between antibiotic and bacteria. This paper proposes a simple dynamic model describing these interactions. The model consists of two non-linear differential equations of the S-system type. Its parameter values are estimated, through the minimization… CONTINUE READING

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