A pertussis toxin-sensitive G protein in hippocampal long-term potentiation.

@article{Goh1989APT,
  title={A pertussis toxin-sensitive G protein in hippocampal long-term potentiation.},
  author={Joanne W. Goh and Peter S. Pennefather},
  journal={Science},
  year={1989},
  volume={244 4907},
  pages={
          980-3
        }
}
High-frequency (tetanic) stimulation of presynaptic nerve tracts in the hippocampal region of the brain can lead to long-term synaptic potentiation (LTP). Pertussis toxin prevented the development of tetanus-induced LTP in the stratum radiatum-CA1 synaptic system of rat hippocampal slices, indicating that a guanosine triphosphate-binding protein (G protein) may be required for the initiation of LTP. This G protein may be located at a site distinct from the postsynaptic neuron (that is, in… CONTINUE READING
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