A pertussis/choleratoxin-sensitive N protein may mediate chemoattractant receptor signal transduction.

@article{Verghese1986APN,
  title={A pertussis/choleratoxin-sensitive N protein may mediate chemoattractant receptor signal transduction.},
  author={Margrith W. Verghese and R. J. Uhing and Ralph Snyderman},
  journal={Biochemical and biophysical research communications},
  year={1986},
  volume={138 2},
  pages={887-94}
}
Chemoattractant receptors on phagocytic leukocytes utilize a guanine nucleotide regulatory (N) protein to activate phospholipase C and subsequent biological responses. Since pertussis toxin inhibits activation of leukocytes by chemoattractants and ribosylates a ca. 40 kD protein in these cells it had generally been assumed that chemoattractant receptors are… CONTINUE READING