A perturbation-based method for calculating explicit likelihood of evolutionary co-variance in multiple sequence alignments

@article{Dekker2004APM,
  title={A perturbation-based method for calculating explicit likelihood of evolutionary co-variance in multiple sequence alignments},
  author={John P. Dekker and Anthony Fodor and Richard W. Aldrich and Gary Yellen},
  journal={Bioinformatics},
  year={2004},
  volume={20 10},
  pages={1565-72}
}
MOTIVATION The constituent amino acids of a protein work together to define its structure and to facilitate its function. Their interdependence should be apparent in the evolutionary record of each protein family: positions in the sequence of a protein family that are intimately associated in space or in function should co-vary in evolution. A recent approach by Ranganathan and colleagues proposes to look at subsets of a protein family, selected for their sequence at one position, to see how… CONTINUE READING
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