A perspective on the epidemiology of acetaminophen exposure and toxicity in the United States.

@article{Blieden2014APO,
  title={A perspective on the epidemiology of acetaminophen exposure and toxicity in the United States.},
  author={Marissa B Blieden and L. Clark Paramore and Dhvani Shah and Rami H Ben-Joseph},
  journal={Expert review of clinical pharmacology},
  year={2014},
  volume={7 3},
  pages={341-8}
}
Acetaminophen is a commonly-used analgesic in the US and, at doses of more than 4 g/day, can lead to serious hepatotoxicity. Recent FDA and CMS decisions serve to limit and monitor exposure to high-dose acetaminophen. This literature review aims to describe the exposure to and consequences of high-dose acetaminophen among chronic pain patients in the US. Each year in the US, approximately 6% of adults are prescribed acetaminophen doses of more than 4 g/day and 30,000 patients are hospitalized… CONTINUE READING

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Safety Communication: Prescription Acetaminophen Products to be Limited to 325 mg Per Dosage Unit; Boxed Warning Will Highlight Potential for Severe Liver Failure

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recommends health care professionals discontinue prescribing and dispensing prescription combination drug products with more than 325 mg of acetaminophen to protect consumers

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