A perspective on the Maillard reaction and the analysis of protein glycation by mass spectrometry: probing the pathogenesis of chronic disease.

@article{Zhang2009APO,
  title={A perspective on the Maillard reaction and the analysis of protein glycation by mass spectrometry: probing the pathogenesis of chronic disease.},
  author={Qibin Zhang and Jennifer M. Ames and Richard D. Smith and John W. Baynes and Thomas O. Metz},
  journal={Journal of proteome research},
  year={2009},
  volume={8 2},
  pages={754-69}
}
The Maillard reaction, starting from the glycation of protein and progressing to the formation of advanced glycation end-products (AGEs), is implicated in the development of complications of diabetes mellitus, as well as in the pathogenesis of cardiovascular, renal, and neurodegenerative diseases. In this perspective review, we provide an overview on the relevance of the Maillard reaction in the pathogenesis of chronic disease and discuss traditional approaches and recent developments in the… CONTINUE READING
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