A perspective on surrogate endpoints in controlled clinical trials.

@article{Molenberghs2004APO,
  title={A perspective on surrogate endpoints in controlled clinical trials.},
  author={Geert Molenberghs and Tomasz Burzykowski and Ariel Alonso and M. Buyse},
  journal={Statistical methods in medical research},
  year={2004},
  volume={13 3},
  pages={177-206}
}
The last couple of decades have seen a large amount of activity in the area of surrogate marker and surrogate endpoint validation, both from a clinical and a statistical perspective. Prentice made a pivotal contribution in the context of a single trial. Subsequently, the framework he proposed has been discussed, criticized, and extended. An important class of extensions considers several rather than a single trial. Recently, a lot of work has been done in this so-called hierarchical or meta… CONTINUE READING

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