A perspective on potential antibody-dependent enhancement of SARS-CoV-2

  title={A perspective on potential antibody-dependent enhancement of SARS-CoV-2},
  author={A. Arvin and Katja Fink and M. Schmid and Andrea L. Cathcart and Roberto Spreafico and C. Havenar-Daughton and A. Lanzavecchia and D. Corti and H. Virgin},
  • A. Arvin, Katja Fink, +6 authors H. Virgin
  • Published 2020
  • Medicine
  • Nature
  • Antibody-dependent enhancement (ADE) of disease is a general concern for the development of vaccines and antibody therapies because the mechanisms that underlie antibody protection against any virus have a theoretical potential to amplify the infection or trigger harmful immunopathology. This possibility requires careful consideration at this critical point in the pandemic of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2… CONTINUE READING