A perspective on epistasis: limits of models displaying no main effect.

@article{Culverhouse2002APO,
  title={A perspective on epistasis: limits of models displaying no main effect.},
  author={Robert C. Culverhouse and Brian K. Suarez and Jennifer W. Lin and Theodore Reich},
  journal={American journal of human genetics},
  year={2002},
  volume={70 2},
  pages={461-71}
}
The completion of a draft sequence of the human genome and the promise of rapid single-nucleotide-polymorphism-genotyping technologies have resulted in a call for the abandonment of linkage studies in favor of genome scans for association. However, there exists a large class of genetic models for which this approach will fail: purely epistatic models with no additive or dominance variation at any of the susceptibility loci. As a result, traditional association methods (such as case/control… CONTINUE READING
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