A perspective on enzyme catalysis.

@article{Benkovic2003APO,
  title={A perspective on enzyme catalysis.},
  author={Stephen J Benkovic and Sharon Hammes-Schiffer},
  journal={Science},
  year={2003},
  volume={301 5637},
  pages={
          1196-202
        }
}
The seminal hypotheses proposed over the years for enzymatic catalysis are scrutinized. The historical record is explored from both biochemical and theoretical perspectives. Particular attention is given to the impact of molecular motions within the protein on the enzyme's catalytic properties. A case study for the enzyme dihydrofolate reductase provides evidence for coupled networks of predominantly conserved residues that influence the protein structure and motion. Such coupled networks have… CONTINUE READING

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