A peroxynitrite decomposition catalyst counteracts sensory neuropathy in streptozotocin-diabetic mice.

@article{Drel2007APD,
  title={A peroxynitrite decomposition catalyst counteracts sensory neuropathy in streptozotocin-diabetic mice.},
  author={Viktor R. Drel and P{\'a}l Pacher and Igor M Vareniuk and Ivan A Pavlov and Olga Ilnytska and Valeriy V Lyzogubov and Jyoti Tibrewala and John T Groves and Irina G. Obrosova},
  journal={European journal of pharmacology},
  year={2007},
  volume={569 1-2},
  pages={48-58}
}
Whereas an important role of free radicals and oxidants in peripheral diabetic neuropathy is well established, the contribution of nitrosative stress and, in particular, of the highly reactive oxidant peroxynitrite, has not been properly explored. Our previous findings implicate peroxynitrite in diabetes-associated motor and sensory nerve conduction deficits and peripheral nerve energy deficiency and poly(ADP-ribose) polymerase activation associated with Type 1 diabetes. In this study the role… CONTINUE READING

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