A perinuclear actin cap regulates nuclear shape.

  title={A perinuclear actin cap regulates nuclear shape.},
  author={Shyam B. Khatau and Christopher M. Hale and Phillip J. Stewart-Hutchinson and Meet S Patel and Colin Lawson Stewart and Peter C. Searson and Didier Hodzic and Denis Wirtz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 45},
Defects in nuclear morphology often correlate with the onset of disease, including cancer, progeria, cardiomyopathy, and muscular dystrophy. However, the mechanism by which a cell controls its nuclear shape is unknown. Here, we use adhesive micropatterned surfaces to control the overall shape of fibroblasts and find that the shape of the nucleus is tightly regulated by the underlying cell adhesion geometry. We found that this regulation occurs through a dome-like actin cap that covers the top… CONTINUE READING
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