A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia.

@article{Button2012APB,
  title={A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia.},
  author={Brian Button and Li-Heng Cai and Camille Ehr{\'e} and Mehmet Kesimer and David B. Hill and John Kieran Sheehan and Richard C. Boucher and Michael Rubinstein},
  journal={Science},
  year={2012},
  volume={337 6097},
  pages={937-41}
}
Mucus clearance is the primary defense mechanism that protects airways from inhaled infectious and toxic agents. In the current gel-on-liquid mucus clearance model, a mucus gel is propelled on top of a "watery" periciliary layer surrounding the cilia. However, this model fails to explain the formation of a distinct mucus layer in health or why mucus clearance fails in disease. We propose a gel-on-brush model in which the periciliary layer is occupied by membrane-spanning mucins and… CONTINUE READING
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Trauma Inj

  • M. P. Kinsky, S. M. Milner, B. Button, M. A. Dubick, G. C. Kramer, J.
  • Adv . Drug Deliv . Rev .
  • 2009

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