A peptidyl-prolyl isomerase, FKBP12, accumulates in Alzheimer neurofibrillary tangles.

@article{Sugata2009API,
  title={A peptidyl-prolyl isomerase, FKBP12, accumulates in Alzheimer neurofibrillary tangles.},
  author={Hisato Sugata and Kazuhiko Matsuo and Taisuke Nakagawa and Mikiko Takahashi and Hideyuki Mukai and Yoshitaka Ono and Kiyoshi Maeda and Haruhiko Akiyama and Toshio Kawamata},
  journal={Neuroscience letters},
  year={2009},
  volume={459 2},
  pages={96-9}
}
We investigated a possible role in Alzheimer's disease (AD) for FKBP12, a peptidyl-prolyl cis-trans isomerase known to be important in protein assembly, folding and transportation by using Western blotting and microscopic analyses in postmortem brain tissues from elderly controls and the patients with AD. FKBP12 was enriched and localized to neuronal cell… CONTINUE READING