Corpus ID: 22852235

A peptidomimetic that specifically inhibits human leukocyte antigen DRB1*0401-restricted T cell proliferation.

  title={A peptidomimetic that specifically inhibits human leukocyte antigen DRB1*0401-restricted T cell proliferation.},
  author={S. Woulfe and C. Bono and M. Zacheis and J. K. Welply and D. Kirschmann and T. Baudino and Y. Wang and D. A. Stone and G. Hanson and J. Vuletich and L. Bedell and B. Schwartz and S. Howard},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={281 2},
  • S. Woulfe, C. Bono, +10 authors S. Howard
  • Published 1997
  • Biology, Medicine
  • The Journal of pharmacology and experimental therapeutics
The ability of a peptidomimetic (SC-67655) to block the peptide binding site of the rheumatoid arthritis-linked human leukocyte antigen encoded by the DRB1*0401 allele was evaluated. The inhibitor bound to purified DRB1*0401 molecules with an affinity similar to that of the well-characterized peptide ligand HA307-319. Cell binding assays demonstrated that, in contrast to the promiscuous HA307-319 peptide, the peptidomimetic was highly specific for DRB1*0401. The inhibitor also blocked… Expand
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