A peptidoglycan recognition protein in innate immunity conserved from insects to humans.

@article{Kang1998APR,
  title={A peptidoglycan recognition protein in innate immunity conserved from insects to humans.},
  author={Daiwu Kang and Gang Liu and Annika Lundstr{\"o}m and Eva Gelius and H{\aa}kan Steiner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 17},
  pages={
          10078-82
        }
}
Innate nonself recognition must rely on common structures of invading microbes. In a differential display screen for up-regulated immune genes in the moth Trichoplusia ni we have found mechanisms for recognition of bacterial cell wall fragments. One bacteria-induced gene encodes a protein that, after expression in the baculovirus system, was shown to be a peptidoglycan recognition protein (PGRP). It binds strongly to Gram-positive bacteria. We have also cloned the corresponding cDNA from mouse… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 164 CITATIONS, ESTIMATED 49% COVERAGE

335 Citations

0102030'00'04'09'14'19
Citations per Year
Semantic Scholar estimates that this publication has 335 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…