A peptide nucleic acid (PNA) is more rapidly internalized in cultured neurons when coupled to a retro-inverso delivery peptide. The antisense activity depresses the target mRNA and protein in magnocellular oxytocin neurons.

Abstract

A peptide nucleic acid (PNA) antisense for the AUG translation initiation region of prepro-oxytocin mRNA was synthesized and coupled to a r etro-inverso peptide that is rapidly taken up by cells. This bioconjugate was internalized by cultured cerebral cortex neurons within minutes, according to the specific property of the vector peptide. The PNA alone also… (More)

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@article{AldrianHerrada1998APN, title={A peptide nucleic acid (PNA) is more rapidly internalized in cultured neurons when coupled to a retro-inverso delivery peptide. The antisense activity depresses the target mRNA and protein in magnocellular oxytocin neurons.}, author={Gudrun Aldrian-Herrada and Michel G Desarm{\'e}nien and H{\'e}l{\`e}ne Orcel and Line Boissin-Agasse and JP. Mery and J Brugidou and Anas Rabie}, journal={Nucleic acids research}, year={1998}, volume={26 21}, pages={4910-6} }