A peptide mimic of the chemotaxis inhibitory protein of Staphylococcus aureus: towards the development of novel anti-inflammatory compounds

@inproceedings{Bunschoten2010APM,
  title={A peptide mimic of the chemotaxis inhibitory protein of Staphylococcus aureus: towards the development of novel anti-inflammatory compounds},
  author={Anton Bunschoten and Johannes H. Ippel and John A. W. Kruijtzer and Louris J Feitsma and Carla J. C. de Haas and Rob M. J. Liskamp and Johan Kemmink},
  booktitle={Amino Acids},
  year={2010}
}
Complement factor C5a is one of the most powerful pro-inflammatory agents involved in recruitment of leukocytes, activation of phagocytes and other inflammatory responses. C5a triggers inflammatory responses by binding to its G-protein-coupled C5a-receptor (C5aR). Excessive or erroneous activation of the C5aR has been implicated in numerous inflammatory diseases. The C5aR is therefore a key target in the development of specific anti-inflammatory compounds. A very potent natural inhibitor of the… CONTINUE READING

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